DRUG REPURPOSING AS AN ANTITUMOR AGENT: DISULFIRAM-MEDIATED CARBONIC ANHYDRASE 12 AND ANION EXCHANGER 2 MODULATION TO INHIBIT CANCER CELL MIGRATION

Drug Repurposing as an Antitumor Agent: Disulfiram-Mediated Carbonic Anhydrase 12 and Anion Exchanger 2 Modulation to Inhibit Cancer Cell Migration

Disulfiram has been used in the treatment of alcoholism and exhibits an anti-tumor effect.However, the intracellular mechanism of anti-tumor activity of Disulfiram remains unclear.In this study, we focused on the modulatory role of Disulfiram via Accessories oncogenic factor carbonic anhydrase CA12 and its associated transporter anion exchanger AE2

read more


Profiled Deck Composite Slab Strength Verification: A Review

The purpose of this article is to present an overview on alternate profiled deck composite slab (PDCS) strength verification devoid of the expensive and complex laboratory procedures in establishing its longitudinal shear capacity.Despite the several deterministic research findings leading to the development of proposals and modifications on the co

read more